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5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [ 1 ] [ 2 ] [ 3 ] They mediate both excitatory and inhibitory neurotransmission .
Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.
15560 Ensembl n/a ENSMUSG00000041380 UniProt P28335 P34968 RefSeq (mRNA) NM_001256761 NM_000868 NM_001256760 NM_008312 RefSeq (protein) NP_000859 NP_001243689 NP_001243690 NP_032338 Location (UCSC) n/a Chr X: 145.75 – 145.98 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The 5-HT 2C receptor is a subtype of the 5-HT2 receptor that binds the endogenous neurotransmitter serotonin (5 ...
3356 15558 Ensembl ENSG00000102468 ENSMUSG00000034997 UniProt P28223 P35363 RefSeq (mRNA) NM_001165947 NM_000621 NM_001378924 NM_172812 RefSeq (protein) NP_000612 NP_001159419 NP_001365853 NP_766400 Location (UCSC) Chr 13: 46.83 – 46.9 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse The 5-HT 2A receptor is a subtype of the 5-HT 2 receptor that belongs to the serotonin receptor ...
The 5-HT 7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). [5] The 5-HT 7 receptor is coupled to G s (stimulates the production of the intracellular signaling molecule cAMP) [6] [7] and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in ...
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. [5] SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic ...
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The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]