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Azelastine, sold under the brand name Astelin among others, is a H 1 receptor-blocking medication primarily used as a nasal spray to treat allergic rhinitis (hay fever) and as eye drops for allergic conjunctivitis. [5] [6] Other uses may include asthma and skin rashes for which it is taken by mouth. [7]
The most common adverse effects noted for second-generation agents include drowsiness, fatigue, headache, nausea and dry mouth. [ 4 ] Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with higher risk for cognitive decline and dementia in older people.
The evidence does not report how antihistamines affect women differently than men. [1] Different studies have reported on antihistamine use in children, with various studies finding evidence that certain antihistamines could be used by children 2 years of age, and other drugs being safer for younger or older children.
"In the 60s, the skin tends to become drier, thinner and more delicate due to decreased natural oil production and a decline in collagen and elastin," said Dr. Hannah Kopelman, host of the podcast ...
Fexofenadine does not readily cross the blood–brain barrier, so is less likely to cause drowsiness in comparison to other antihistamines that readily cross that barrier (i.e., first-generation antihistamines such as diphenhydramine). In general, fexofenadine takes about an hour to take effect, though this may be affected by the choice of ...
Flunarizine is a selective calcium antagonist with moderate other actions including antihistamine, serotonin receptor blocking and dopamine D 2 blocking activity. Compared to other calcium channel blockers such as dihydropyridine derivatives, verapamil and diltiazem, flunarizine has low affinity to voltage-dependent calcium channels.
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