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Kaposi's sarcoma (KS) is a type of cancer that can form masses on the skin, in lymph nodes, in the mouth, or in other organs. [ 4 ] [ 6 ] The skin lesions are usually painless, purple and may be flat or raised.
People with HHV-8-associated MCD may experience enlarged lymph nodes in multiple lymph node regions; systemic symptoms, such as fever, night sweats, unintended weight loss, and fatigue; rashes such as cherry hemangiomas or Kaposi sarcoma; enlargement of the liver and/or spleen; and extravascular fluid accumulation in the extremities (), abdomen (), or lining of the lungs (pleural effusion).
Some cases of PEL also involve the gastrointestinal tract and lymph nodes. The disease occurs primarily in people who are immunosuppressed or test positive for HIV [12] and are also latently infected with Kaposi's sarcoma-associated herpesvirus; [13] PEL is an aggressive disease with an overall 1 year survival rate of ~30%. [13]
Kaposi sarcoma (a cancer of the blood vessel lining and lymph nodes, only in men) Rates doubled or even tripled for some of these cancers, including kidney, pancreatic and small intestine cancers ...
Castleman disease (CD) is a lymphoproliferative disorder of unknown cause. [5] CD is associated with an increased risk of B-cell lymphoma. [5]Human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus (KSHV) has been found in some cases of multicentric Castleman disease (MCD).
Kaposi's sarcoma-associated herpesvirus (KSHV) is the ninth known human herpesvirus.It is also called Human herpesvirus 8, or HHV-8 in short. [2] This virus causes Kaposi's sarcoma, a cancer commonly occurring in AIDS patients, [3] as well as primary effusion lymphoma, [4] HHV-8-associated multicentric Castleman's disease and KSHV inflammatory cytokine syndrome. [5]