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Shiga-like toxin (SLT) is a historical term for similar or identical toxins produced by Escherichia coli. [3] The most common sources for Shiga toxin are the bacteria ...
The verocytotoxin (shiga-like toxin) can directly damage renal and endothelial cells. Thrombocytopenia occurs as platelets are consumed by clotting. Hemolytic anemia results from intravascular fibrin deposition, increased fragility of red blood cells, and fragmentation.
Referred to as E. coli O157:H7 or Shiga toxin-producing E. coli (STEC), this strain of E. coli can be particularly dangerous and even life-threatening. The primary sources of STEC outbreaks are ...
Escherichia coli O157:H7 is a serotype of the bacterial species Escherichia coli and is one of the Shiga-like toxin–producing types of E. coli.It is a cause of disease, typically foodborne illness, through consumption of contaminated and raw food, including raw milk and undercooked ground beef.
Roughly 10 million cases of foodborne illness each year in the U.S. are caused by six pathogens — salmonella, listeria monocytogenes, campylobacter, clostridium perfringens, shiga toxin ...
Some exotoxins act directly at the ribosome to inhibit protein synthesis. An example is Shiga toxin. Other toxins act at elongation factor-2. In the case of the diphtheria toxin, EF2 is ADP-ribosylated and becomes unable to participate in protein elongation, and, so, the cell dies. Pseudomonas exotoxin has a similar action.
Tests for toxin production can use mammalian cells in tissue culture, which are rapidly killed by shiga toxin. Although sensitive and very specific, this method is slow and expensive. [49] Typically, diagnosis has been done by culturing on sorbitol-MacConkey medium and then using typing antiserum.
The type of E. coli named in the 4Earth Farms recall, Shiga toxin-producing E. coli O121:H19, can cause serious and sometimes fatal infections in some of the vulnerable groups noted above ...