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The International Prognostic Index (IPI) is a clinical tool developed by oncologists to aid in predicting the prognosis of patients with aggressive non-Hodgkin's lymphoma. Previous to IPI's development, the primary consideration in assessing prognosis was the Ann Arbor stage alone, but this was increasingly found to be an inadequate means of ...
Similarly, double-expressor DLBCL, characterized by co-expression of MYC and BCL2, albeit without associated translocations, presents elevated CNS relapse risks, particularly in conjunction with high CNS-IPI scores.
Diffuse large B-cell lymphoma (DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies.It is the most common form of non-Hodgkin lymphoma among adults, [1] with an annual incidence of 7–8 cases per 100,000 people per year in the US and UK.
A study of DLBCL cell lines indicated that 14-3-3ζ proteins may play a role in mediating resistance of DLBCL cells to CHOP. 14-3-3 proteins exert anti-apoptotic activity by interfering with the function of BH3-only proteins and has been validated as a potential molecular target for anticancer therapeutic development in other types of cancers.
Primary central nervous system lymphoma (PCNSL), also termed primary diffuse large B-cell lymphoma of the central nervous system (DLBCL-CNS), [2] is a primary intracranial tumor appearing mostly in patients with severe immunodeficiency (typically patients with AIDS). It is a subtype and one of the most aggressive of the diffuse large B-cell ...
As of 2022, the most commonly used prognostic score is the CLL International Prognostic Index (CLL-IPI). [45] This system takes into account the following factors: [45] TP53 gene deletion and/or mutation; Mutated immunoglobulin heavy chain variable (IGHV) Serum B 2-microglobulin levels; Clinical stage (see the Rai and Binet staging systems ...
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