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  2. Alpha-thalassemia - Wikipedia

    en.wikipedia.org/wiki/Alpha-thalassemia

    Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 [5] and HBA2. [6] Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin , the molecule that carries oxygen in the blood. [ 7 ]

  3. Hemoglobin A2 - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_A2

    Beta-thalassemia has beta globin chains that are reduced and alpha-thalassemia has alpha globin chains that are also reduced. [5] This disorder is the most common autosomal recessive disorder in some countries. [6] Hemoglobin A2 is employed to diagnose thalassemia disorders, encompassing both beta and alpha types.

  4. Thalassemia - Wikipedia

    en.wikipedia.org/wiki/Thalassemia

    Carriers of thalassemia genes may have no symptoms (thalassemia minor), very mild symptoms with occasional crisis (thalassemia intermedia) or severe and life threatening symptoms (thalassemia major). [17] Alpha thalassemia major is generally fatal to the unborn child, as zero functional hemoglobin is produced during gestation.

  5. Hemoglobin A - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_A

    Alpha-thalassemia (α-thalassemia) is defined by a lack of α-globin chain production in hemoglobin, and those who carry a mutation impacting the α-globin chain on only one chromosome are considered to have a “silent” α-thalassemia whereas, if the mutation is on both then it is considered an α-thalassemia trait.

  6. Hemoglobin Barts - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_Barts

    If hemoglobin Barts is detected on a newborn screen, the patient is usually referred for further evaluation since detection of hemoglobin Barts can indicate either one alpha globin gene deletion, making the baby a silent alpha thalassemia carrier, two alpha globin gene deletions (alpha thalassemia), or hemoglobin H disease (three alpha globin ...

  7. Human genetic resistance to malaria - Wikipedia

    en.wikipedia.org/wiki/Human_genetic_resistance...

    In α-thalassemia, which is relatively frequent in Africa and several other countries, production of the α-chain of hemoglobin is impaired, and there is relative over-production of the β-chain. Individuals homozygous for β-thalassemia have severe anemia and are unlikely to survive and reproduce, so selection against the gene is strong.

  8. List of hematologic conditions - Wikipedia

    en.wikipedia.org/wiki/List_of_hematologic_conditions

    Alpha-thalassemia: D56.0: 448, 33334, 33678: Alpha-thalassemia (α-thalassemia) is a form of thalassemia involving the genes HBA1 [20] and HBA2. [21] It is condition that causes a reduction of hemoglobin production. There are two types of Alpha-thalassemia, named hemoglobin Bart hydrops fetalis syndrome (also known as Hb Bart syndrome) and HbH ...

  9. Sickle cell trait - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_trait

    The trait is known to cause significantly fewer deaths due to malaria, especially when Plasmodium falciparum is the causative organism. This is a prime example of natural selection , evidenced by the fact that the geographical distribution of the gene for hemoglobin S and the distribution of malaria in Africa virtually overlap.

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