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When injected into the penis for erectile dysfunction; side effects may include penile pain, bleeding at the site of injection, and prolonged erection (priapism). [2] Prostaglandin E 1 is in the vasodilator family of medications. [2] It works by opening blood vessels and relaxing smooth muscle. [2]
Safety is an essential factor to consider before using any type of medication, and treatments for ED are no exception. Luckily, ED is a treatable issue with a number of well-known options.
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4] [8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9]
While the active drugs in Trimix have all been individually approved by the U.S. Food and Drug Administration (FDA), Trimix as a combination drug has not been approved by the FDA and is only available from compounding pharmacies. [1] [3] [10] Trimix is typically prepared by the compounding pharmacy in a sterile environment and then frozen. [11]
For those in need of a tried-and-true treatment for ED, the best bet may be FDA-approved oral medications known as phosphodiesterase type 5 (PDE5) inhibitors. Similar to nitric oxide, PDE5 ...