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The dosage to be used cannot be determined with precision, as no reliable relation between dose and effect could be established so far. [1] The toxicity of botulinum toxin varies from one lot to the next; furthermore, the body may show an immunoreaction by which the efficacy of subsequent treatments is reduced.
More evidence related to the frequency and dosage of injections as it relates to long-term outcomes is needed in order to support or refute the use of botulinum toxin in the management of lower limb spasticity in children with cerebral palsy. [65] Dosages of botulinum toxin have been based on expert opinion rather than evidence-based practices.
Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. [24] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. [25]
Spastic diplegia is a form of cerebral palsy (CP) that primarily affects the legs, with possible considerable asymmetry between the two sides. It is a chronic neuromuscular condition of hypertonia and spasticity in the muscles of the lower extremities of the human body, manifested as an especially high and constant "tightness" or "stiffness", [1] [2] usually in the legs, hips and pelvis.
Additionally, traditional Botox tends to work more quickly than Botox in-a-bottle products, which take longer to provide the expected smoothing, and lifting results. Plus, these products need to ...
Spasticity affects roughly a quarter of all stroke patients. In the days following a stroke, a patient's muscles, especially in the arms and legs, are often weak and limp. Then a few weeks later ...
Spasticity is often treated with the drug baclofen, which acts as an agonist at GABA receptors, which are inhibitory. Spastic cerebral palsy is the most common form of cerebral palsy , which is a group of permanent movement problems that do not get worse over time.
Botox also may be a better choice for those who can’t take other migraine medications due to potential drug interactions, other underlying health conditions, or side effects caused by oral medicine.
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