Search results
Results From The WOW.Com Content Network
Human polyomavirus 2, commonly referred to as the JC virus or John Cunningham virus, is a type of human polyomavirus (formerly known as papovavirus). [3] It was identified by electron microscopy in 1965 by ZuRhein and Chou, [ 4 ] and by Silverman and Rubinstein.
Polyomaviridae is a family of viruses whose natural hosts are primarily mammals and birds. [1] [2] As of 2024, there are eight recognized genera. [3]Fourteen species are known to infect humans, while others, such as Simian Virus 40, have been identified in humans to a lesser extent.
Agnoprotein is typically quite short: examples from BK virus, JC virus, and SV40 are 62, 71, and 66 amino acid residues long, respectively. Among other known polyomavirus genomes with a predicted agnogene, the length of the resulting predicted protein varies considerably, from as short as 30 to as long as 154 residues. [3]
Major capsid protein VP1 is a viral protein that is the main component of the polyomavirus capsid.VP1 monomers are generally around 350 amino acids long and are capable of self-assembly into an icosahedral structure consisting of 360 VP1 molecules organized into 72 pentamers.
The circular genome of a representative polyomavirus, WU polyomavirus, with the late region at right indicating positions of the VP1, VP2, and VP3 genes. [4]All three capsid proteins are expressed from alternative start sites on a single transcript of the "late region" of the circular viral chromosome (so named because it is transcribed late in the process of viral infection).
The BK virus, also known as Human polyomavirus 1, is a member of the polyomavirus family. Past infection with the BK virus is widespread, [1] but significant consequences of infection are uncommon, with the exception of the immunocompromised and the immunosuppressed. BK virus is an abbreviation of the name of the first patient, from whom the ...
Discover the latest breaking news in the U.S. and around the world — politics, weather, entertainment, lifestyle, finance, sports and much more.
The cause of PML is a type of polyomavirus called the JC virus (JCV), after the initials of the person (John Cunningham) from whose tissue the virus was first successfully cultured. Publications indicate 39 [ 3 ] to 58% [ 4 ] of the general population are seropositive for antibodies to JCV, indicating current or previous infection with the virus.