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The dorsal root ganglion is not separated by a blood brain barrier as it contains fenestrated capillaries which are highly permeable. This allows antibodies, T-cells, toxins and other substances to enter, causing damage to the nerve cell bodies. [2] Paraneoplastic sensory neuropathy occurs in the setting of cancer and is thought to involve anti ...
Tabes dorsalis is a late consequence of neurosyphilis, characterized by the slow degeneration (specifically, demyelination) of the neural tracts primarily in the dorsal root ganglia of the spinal cord (nerve root). These patients have lancinating nerve root pain which is aggravated by coughing, and features of sensory ataxia with ocular ...
A dorsal root ganglion (or spinal ganglion; also known as a posterior root ganglion [1]) is a cluster of neurons (a ganglion) in a dorsal root of a spinal nerve. The cell bodies of sensory neurons known as first-order neurons are located in the dorsal root ganglia. [2] The axons of dorsal root ganglion neurons are known as afferents.
Procedures include neurectomy, cordotomy, dorsal root entry zone lesioning, and cingulotomy. Cutting through or removal of nerves is used in people with cancer pain who have short life expectancy and who are unsuitable for drug therapy due to ineffectiveness or intolerance. Because nerves often carry both sensory and motor fibers, motor ...
Chemotherapy-induced peripheral neuropathy (CIPN) is a nerve-damaging side effect of antineoplastic agents in the common cancer treatment, chemotherapy. [1] CIPN afflicts between 30% and 40% of patients undergoing chemotherapy.
Tarlov cysts are most commonly located in the S1 to S4/S5 region of the spinal canal, but can be found along any region of the spine.They usually form on the extradural components of sacrococcygeal nerve roots at the junction of dorsal root ganglion and posterior nerve roots and arise between the endoneurium and perineurium. [10]
A ganglion (pl.: ganglia) is a group of neuron cell bodies in the peripheral nervous system. In the somatic nervous system , this includes dorsal root ganglia and trigeminal ganglia among a few others.
The dorsal root or dorsal root ganglion (that carry mostly sensory signals) may be usefully targeted (called rhizotomy); with the dorsal root ganglion possibly the more effective target because some sensory fibers enter the spinal cord from the dorsal root ganglion via the ventral (motor) root, and these would not be interrupted by dorsal root ...