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Depot injections can be created by modifying the drug molecule itself, as in the case of prodrugs, or by modifying the way it is administered, as in the case of oil/lipid suspensions. Depot injections can have a duration of action of one month or greater and are available for many types of drugs, including antipsychotics and hormones .
Methylprednisolone acetate, sold under the brand names Depo-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 acetate ester of methylprednisolone—which is used in clinical and veterinary medicine.
The injection site must be cleaned before administering the injection, and the injection is then administered in a fast, darting motion to decrease the discomfort to the individual. The volume to be injected in the muscle is usually limited to 2–5 milliliters, depending on injection site. A site with signs of infection or muscle atrophy ...
Depo-Provera is the brand name for a 150 mg microcrystalline aqueous suspension of DMPA that is administered by intramuscular injection. The shot must be injected into thigh, buttock, or deltoid muscle four times a year (every 11 to 13 weeks), and provides pregnancy protection instantaneously after the first injection. [ 68 ]
Some depot injections are also administered intramuscularly, including medroxyprogesterone acetate among others. [11] In addition to medications, most inactivated vaccines, including the influenza vaccine, are given as an IM injection. [12]
Microcrystalline estradiol benzoate in aqueous suspension (brand names Agofollin Depot and Ovocyclin M alone and Follivirin in combination with testosterone isobutyrate) [33] [39] has been found to have a longer duration of action than amorphous estradiol benzoate in oil solution when administered via intramuscular injection.
It is given by mouth, injection into a muscle, or just under the skin. [2] There is also a long acting injectable version that may last for up to four weeks. [2] Fluphenazine decanoate, the depot injection form of fluphenazine, should not be used by people with severe depression. [5]
Clopixol Depot: Typical: Viscoleo b: 50–800 mg/2–4 weeks: 4–9 days? 11–21 days: 7.5–9.0: Note: All by intramuscular injection. Footnotes: a = Microcrystalline or nanocrystalline aqueous suspension. b = Low-viscosity vegetable oil (specifically fractionated coconut oil with medium-chain triglycerides). c = Predicted, from PubChem and ...