Search results
Results From The WOW.Com Content Network
Depot injections can be created by modifying the drug molecule itself, as in the case of prodrugs, or by modifying the way it is administered, as in the case of oil/lipid suspensions. Depot injections can have a duration of action of one month or greater and are available for many types of drugs, including antipsychotics and hormones .
Depo-Provera is the brand name for a 150 mg microcrystalline aqueous suspension of DMPA that is administered by intramuscular injection. The shot must be injected into thigh, buttock, or deltoid muscle four times a year (every 11 to 13 weeks), and provides pregnancy protection instantaneously after the first injection. [68]
Some depot injections are also administered intramuscularly, including medroxyprogesterone acetate among others. [11] In addition to medications, most inactivated vaccines, including the influenza vaccine, are given as an IM injection.
Medications administered in the muscle may also be administered as depot injections, which provide slow, continuous release of medicine over a longer period of time. [3] Certain substances, including ketamine, may be injected intramuscularly for recreational purposes. [4]
It is usually a depot injection, either subcutaneous or intradermal, and not an intramuscular injection. After deposition, the drug then diffuses slowly from the depot into the capillary networks, where it enters circulation. Skin popping is distinct from intravenous injection in that the latter deposits the drug directly into the bloodstream ...
Testosterone undecanoate has a very long elimination half-life and mean residence time when given as a depot intramuscular injection. [27] [7] [8] Its elimination half-life is 20.9 days and its mean residence time is 34.9 days in tea seed oil, while its elimination half-life is 33.9 days and its mean residence time is 36.0 days in castor oil.
It is given by mouth, injection into a muscle, or just under the skin. [2] There is also a long acting injectable version that may last for up to four weeks. [2] Fluphenazine decanoate, the depot injection form of fluphenazine, should not be used by people with severe depression. [5]
Esters of estradiol like estradiol undecylate are readily hydrolyzed prodrugs of estradiol, but have an extended duration when administered in oil via intramuscular injection due to a depot effect afforded by their fatty acid ester moiety. [5] As prodrugs of estradiol, estradiol undecylate and other estradiol esters are estrogens.