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The study used a mixed model to assess differences in average weight change over time (from baseline to the end of the study: 72 weeks for SM-1 to SM-3 and 88 weeks for SM-4).
Let's look at the research: People who took the maximum dose of tirzepatide over 72 weeks lost an average of 21 percent of their body weight, according to data from clinical trials published in ...
Because Eli Lilly's tirzepatide did not hit the market as Mounjaro for diabetes until 2022 and Zepbpund for weight loss until 2023, the study had a small number of people on this medication.
About 82% of participants taking tirzepatide experienced 5% or greater weight loss. In comparison, only 66.5% of participants taking semaglutide achieved this level of weight loss. Which one to choose
For the efficacy estimand, tirzepatide led to a 15.7% (in a combined population of people with and without type 2 diabetes) body weight reduction compared to 2.2% for placebo.
In both trials, after 72 weeks of treatment, participants who received tirzepatide at all three dose levels experienced a statistically significant reduction in body weight compared to those who received placebo, and greater proportions of participants who received tirzepatide achieved at least 5% weight reduction compared to placebo. [16]
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