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When looking at specific weight loss thresholds, both men and women were far more likely to achieve reductions of 5%, 10%, and 15% body weight with tirzepatide compared to placebo.
About 82% of participants taking tirzepatide experienced 5% or greater weight loss. In comparison, only 66.5% of participants taking semaglutide achieved this level of weight loss. Which one to choose
For the efficacy estimand, tirzepatide led to a 15.7% (in a combined population of people with and without type 2 diabetes) body weight reduction compared to 2.2% for placebo.
Because Eli Lilly's tirzepatide did not hit the market as Mounjaro for diabetes until 2022 and Zepbpund for weight loss until 2023, the study had a small number of people on this medication.
Tirzepatide, a dual agonist of GLP-1 and GIP receptors, is approved for type 2 diabetes and obesity.With an average 20 percent weight loss at a high dosage, it appears to be more effective than GLP-1 mono agonists although there have been no head to head trials as of 2023.
Tirzepatide [12] is an antidiabetic medication used for the treatment of type 2 diabetes [9] [13] [14] [15] and for weight loss. [ 10 ] [ 16 ] Tirzepatide is administered via subcutaneous injections (under the skin).
According to an Eli Lilly-sponsored study, 10 to 15 milligrams of once-weekly tirzepatide can reduce appetite and food intake, both of which promote weight loss. 5. Metformin
Tirzepatide (Mounjaro) Effectiveness for Weight Loss A 2023 systematic review and meta-analysis looked into 14 trials of tirzepatide on more than 11,000 people with type 2 diabetes.
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