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Withdrawal from alcohol induces a surge in release of excitatory neurotransmitters like glutamate, which activates NMDARs. [27] Acamprosate reduces this glutamate surge. [28] The drug also protects cultured cells from excitotoxicity induced by ethanol withdrawal [29] and from glutamate exposure combined with ethanol withdrawal. [30]
U.S. officials have approved a new type of pain drug designed to eliminate the risks of addiction and overdose associated with opioids. ... Studies in more than 870 patients with acute pain due to ...
The granddad finally got sober at 50 by getting monthly shots of a drug that manages his cravings. This as-told-to essay is based on a conversation with Jeff Horton, 50, a development operations ...
Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme aldehyde dehydrogenase (specifically the ALDH2 enzyme [3]), causing many of the effects of a hangover to be felt immediately following alcohol consumption.
A new opioid-free pain medication was approved by the U.S. Food and Drug Administration (FDA) on Thursday, marking a non-addictive alternative for patients. Journavx (suzetrigine), made by Vertex ...
Alcoholic polyneuropathy is a neurological disorder in which peripheral nerves throughout the body malfunction simultaneously.It is defined by axonal degeneration in neurons of both the sensory and motor systems and initially occurs at the distal ends of the longest axons in the body.