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A familial tendency to develop autoimmune diseases suggests a genetic component. Some conditions, like lupus and multiple sclerosis, often occur in several members of the same family, indicating a potential hereditary link. Additionally, certain genes have been identified that increase the risk of developing specific autoimmune diseases.
Scientists have never been able to explain why women are at such greater risk of autoimmune disease, but new research published in Cell on February 1 could hold the answer. And the key lies in the ...
Most autoimmune diseases are sex-related; as a whole, women are much more likely to develop autoimmune disease than men. Being female is the single greatest risk factor for developing autoimmune disease than any other genetic or environmental risk factor yet discovered.
Histone methylation is also implicated in autoimmune disorders. This can be by inhibition of histone methylation such as in systemic sclerosis or by elevated histone methylation at certain gene loci in Type I diabetes. [4] Histone modification can give rise to rheumatic, endocrinological, and gastrointestinal autoimmune disorders.
What experts say about the connection between the immune system and autoimmune disorders like MS, lupus, arthritis, and others.
Doctors debate whether MS is an autoimmune disorder, arguing that it could possibly be a neurodegenerative disorder instead. Scientists have also made headway into several cause-related theories.
Autoimmune diseases can result in systemic or localized symptoms, depending on the given disease. [8] Typical systemic symptoms include fevers, fatigue, muscle aches, joint pain, and rashes; these can be seen in diseases such as lupus or rheumatoid arthritis. Other autoimmune diseases have localized effects on specific organ or tissue types.
Chronic systemic inflammation is the result of release of pro-inflammatory cytokines from immune-related cells and the chronic activation of the innate immune system.It can contribute to the development or progression of certain conditions such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, autoimmune and neurodegenerative ...