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Mucositis can occur anywhere along the gastrointestinal (GI) tract, but oral mucositis refers to the particular inflammation and ulceration that occurs in the mouth. [2] Oral mucositis is a common and often debilitating complication of cancer treatment.
Palifermin reduces the incidence and duration of severe oral mucositis [4] [5] by protecting those cells and stimulating the growth of new epithelial cells to build up the mucosal barrier. Palifermin is also being studied in the prevention and treatment of oral mucositis and dysphagia (difficulty swallowing) in other types of cancer. [2]
It is called plasma cell gingivitis where the gingiva (gums) are involved, [5] plasma cell cheilitis, [5] where the lips are involved, and other terms such as plasma cell orifacial mucositis, [5] or plasma cell gingivostomatitis where several sites in the mouth are involved. On the lips, the condition appears as sharply outlined, infiltrated ...
Gelclair can be used in the management of the painful symptoms of oral mucositis usually caused by radiotherapy or chemotherapy treatment for cancer but can also be caused by medication, disease, oral surgery, stress, traumatic ulcers caused by dental braces and dentures, and ageing. Gelclair can be used by patients of all ages.
Aphthous ulcer and stomatitis due to radiation or chemotherapy—The 2013 guidelines of the International Society of Oral Oncology does not recommended sucralfate for the prevention of oral mucositis in head and neck cancer patients receiving radiotherapy or chemoradiation due to a lack of efficacy found in a randomized controlled trial. [16]
Oral lidocaine is useful for the treatment of mucositis symptoms (inflammation of mucous membranes) induced by radiation or chemotherapy. [82] There is evidence that lidocaine anesthetic mouthwash has the potential to be systemically absorbed, when it was tested in patients with oral mucositis who underwent a bone marrow transplant. [83]
The treatment arm received 4 topical fluoride treatments plus Caphosol, while the control arm received a fluoride rinse (0.01% NaF aqueous solution). Patients were instructed to rinse 4 times per day at the start of cancer treatment and up to 10 times per day if they developed severe oral mucositis. The results showed:
It appears as reddened but painless mucosa beneath the denture. 90% of cases are associated with Candida species, and it is the most common form of oral candidiasis. Treatment is by antifungal medication and improved dental hygiene, such as not wearing the denture during sleep.