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A lower dose should be used in people with liver disease. [2] While it does not appear to be harmful during pregnancy, it has not been studied for this use. [3] It is unclear if it is safe for use during breastfeeding. [2] It is in the antihelmintic family of medications. [4] It works by paralyzing worms. [4] Pyrantel was initially described in ...
March 1, 2016 Gilead Sciences Yes Descovy: emtricitabine tenofovir alafenamide April 4, 2016 Gilead Sciences No Juluca: rilpivirine dolutegravir November 21, 2017 ViiV Healthcare Yes Symfi, Symfi Lo: lamivudine tenofovir disoproxil efavirenz February 5, 2018 (Symfi Lo) March 22, 2018 (Symfi) Mylan: Yes Biktarvy: emtricitabine tenofovir ...
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) of HIV-1. Tenofovir is a nucleotide reverse transcriptase inhibitor of HIV-1, and it can be classified as an NtRTI. These three drugs work in combination to target the HIV reverse transcriptase protein in three ways, which reduces the virus's capacity to mutate. [5]
Efavirenz is chemically described as (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one. Its empirical formula is C 14 H 9 ClF 3 NO 2. Efavirenz is a white to slightly pink crystalline powder with a molecular mass of 315.68 g/mol. It is practically insoluble in water (<10 μg/mL).
In fixed-dose combinations with tenofovir or with efavirenz and tenofovir it is on the World Health Organization's List of Essential Medicines. [4] A fixed-dose triple combination of emtricitabine, tenofovir and efavirenz (Sustiva, marketed by Bristol-Myers Squibb) was approved by the U.S. Food and Drug Administration (FDA) on July 12, 2006 ...
A combination drug or a fixed-dose combination (FDC) is a medicine that includes two or more active ingredients combined in a single dosage form. [1] Terms like "combination drug" or "combination drug product" can be common shorthand for an FDC product (since most combination drug products are currently FDCs), although the latter is more precise if in fact referring to a mass-produced product ...
The procedure is to take the child's weight in pounds, divide by 150 lb, and multiply the fractional result by the adult dose to find the equivalent child dosage.For example, if an adult dose of medication calls for 30 mg and the child weighs 30 lb, divide the weight by 150 (30/150) to obtain 1/5 and multiply 1/5 times 30 mg to get 6 mg.
A pentavalent vaccine combines five vaccines into one dose. Pentavalent vaccines include: DTwP-HepB-Hib vaccine, used by UNICEF in low/middle income countries; DTaP-IPV/Hib vaccine, used in the UK until 2017 (replaced by a hexavalent vaccine) DTaP-IPV-HepB vaccine, approved in the US