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The power of twin designs arises from the fact that twins may be either identical (monozygotic (MZ), i.e. developing from a single fertilized egg and therefore sharing all of their polymorphic alleles) or fraternal (dizygotic (DZ), i.e. developing from two fertilized eggs and therefore sharing on average 50% of their alleles, the same level of genetic similarity found in non-twin siblings).
Monozygotic twins are genetically nearly identical and they are the same chromosomal sex unless there has been a mutation during development. The children of monozygotic twins test genetically as half-siblings (or full siblings, if a pair of monozygotic twins reproduces with another pair or with the same person), rather than first cousins.
Twins are concordant when both have or both lack a given trait. [1] The ideal example of concordance is that of identical twins, because the genome is the same, an equivalence that helps in discovering causation via deconfounding, regarding genetic effects versus epigenetic and environmental effects (nature versus nurture).
No two humans are genetically identical. Even monozygotic twins (who develop from one zygote) have infrequent genetic differences due to mutations occurring during development and gene copy-number variation. [1] Differences between individuals, even closely related individuals, are the key to techniques such as genetic fingerprinting.
The word zygosity may also be used to describe the genetic similarity or dissimilarity of twins. [6] Identical twins are monozygotic, meaning that they develop from one zygote that splits and forms two embryos. Fraternal twins are dizygotic because they develop from two separate oocytes (egg cells) that are fertilized by two separate sperm.
Back when they were single, identical twins sisters Venessa and Kerissa Sealby never dreamed they would marry identical twin brothers. “We didn’t have any interest in dating twins,” Venessa ...
Identical twins of the ‘Ask Reddit’ community recently shared what are the main differences between them and their sibling, showing that the dissimilarities can range from a unique mole to one ...
Monozygotic twins also known as identical twins are siblings that share the same genetic information because of their prenatal development. Monozygotic twins result from the fertilization of one egg and the division of that single embryo forming two embryos. [ 4 ]