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  2. Nerve injury - Wikipedia

    en.wikipedia.org/wiki/Nerve_injury

    Nerve growth factor (NGF) typically has a low level of expression in nerves that are healthy and not growing or developing, but in response to nerve injury NGF expression increases in Schwann cells. This is a mechanism to increase growth and proliferation of Schwann cells at the distal stump in order to prepare for reception of the regenerating ...

  3. Neuroregeneration - Wikipedia

    en.wikipedia.org/wiki/Neuroregeneration

    Guillain–Barré syndrome – nerve damage. Neuroregeneration in the peripheral nervous system (PNS) occurs to a significant degree. [5] [6] After an injury to the axon, peripheral neurons activate a variety of signaling pathways which turn on pro-growth genes, leading to reformation of a functional growth cone and regeneration.

  4. Erythropoietin in neuroprotection - Wikipedia

    en.wikipedia.org/wiki/Erythropoietin_in_neuro...

    [2] [3] Epo has also been reported to enhance nerve recovery after spinal trauma. Celik and associates investigated motor neuron apoptosis in rabbits with a transient global spinal ischemia model. [4] The functional neurological status of animals given RhEpo was better after recovery from anesthesia, and kept improving over a two-day period.

  5. Neurotrophic factors - Wikipedia

    en.wikipedia.org/wiki/Neurotrophic_factors

    In the mature nervous system, they promote neuronal survival, induce synaptic plasticity, and modulate the formation of long-term memories. [2] Neurotrophic factors also promote the initial growth and development of neurons in the central nervous system and peripheral nervous system , and they are capable of regrowing damaged neurons in test ...

  6. Marion Buckwalter - Wikipedia

    en.wikipedia.org/wiki/Marion_Buckwalter

    Marion Buckwalter is an American neurologist and neuroscientist and Professor of Neurology and Neurosurgery at the Stanford University School of Medicine.Buckwalter studies how inflammatory responses affect brain recovery after injury or insult, with a specific emphasis on the neuroimmune and glial cell response after stroke.

  7. Neurodegenerative disease - Wikipedia

    en.wikipedia.org/wiki/Neurodegenerative_disease

    Amyloid beta is a fragment from a larger protein called amyloid precursor protein (APP), a transmembrane protein that penetrates through the neuron's membrane. APP appears to play roles in normal neuron growth, survival and post-injury repair. [18] [19] APP is cleaved into smaller fragments by enzymes such as gamma secretase and beta secretase ...

  8. Wallerian degeneration - Wikipedia

    en.wikipedia.org/wiki/Wallerian_degeneration

    Wallerian degeneration is an active process of degeneration that results when a nerve fiber is cut or crushed and the part of the axon distal to the injury (which in most cases is farther from the neuron's cell body) degenerates. [1]

  9. Glial cell line-derived neurotrophic factor - Wikipedia

    en.wikipedia.org/wiki/Glial_cell_line-derived...

    The GDNF gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF is synthesized as a 211 amino acid-long protein precursor, pro-GDNF. [9]