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In light of recent evidence, olanzapine (Zyprexa) has been FDA approved as an effective monotherapy for the maintenance of bipolar disorder. [22] A head-to-head randomized control trial in 2005 has also shown olanzapine monotherapy to be just as effective and safe as lithium in prophylaxis. [23]
Lithium is the "classic" mood stabilizer, the first to be approved by the US FDA, and still popular in treatment. Therapeutic drug monitoring is required to ensure lithium levels remain in the therapeutic range: 0.6 to 0.8 or 0.8–1.2 mEq/L (or millimolar). Signs and symptoms of toxicity include nausea, vomiting, diarrhea, and ataxia. [3]
Lamotrigine is approved in the US for maintenance treatment of bipolar I disorder and bipolar II disorder. [25] While the anticonvulsants carbamazepine and valproate are predominantly antimanics , lamotrigine has demonstrated efficacy only in preventing or reducing the risk of recurrent depressive episodes of bipolar disorder.
It is approved by the FDA for the following indications: schizophrenia. acute treatment of manic or mixed episodes associated with bipolar I disorder and maintenance treatment of bipolar I disorder. adjunct to lithium or valproate in the treatment of manic or mixed episodes associated with bipolar I disorder.
In 1970, lithium was approved by the United States Food and Drug Administration (FDA) for the treatment of bipolar disorder, which remains its primary use in the US. [ 5 ] [ 17 ] It is sometimes used when other treatments are not effective in a number of other conditions, including major depression , [ 18 ] schizophrenia , disorders of impulse ...
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