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Because of its long elimination half-life, dutasteride requires 5 to 6 months to reach steady-state concentrations. [59] It also remains in the body for a long time after discontinuation and can be detected up to 4 to 6 months. [1] [2] In contrast to dutasteride, finasteride has a short terminal half-life of only 5 to 8 hours.
Dutasteride was approved for the treatment of BPH in 2001 and was subsequently approved for pattern hair loss in South Korea in 2009 and in Japan in 2015. [ 44 ] [ 45 ] The patent protection on finasteride and dutasteride has expired and both drugs are available as generic medications .
A dosage of bicalutamide of 2 mg/kg (or about 40 to 60 mg in boys that are 20 to 30 kg or 45 to 65 lbs) once daily is recommended for use in male peripheral precocious puberty. [149] Bicalutamide is used to block the actions of androgens in the condition, while the aromatase inhibitor is used to decrease levels of estrogens. [148]
[3] [55] Due to its strong antigonadotropic effects and suppression of androgen and estrogen levels, CPA is associated with marked sexual dysfunction (including loss of libido and impotence) similar to that seen with castration, [37] [18] [97] and osteoporosis, [98] whereas such side effects occur minimally with NSAAs like bicalutamide.
But some research has noted rare but serious side effects of once-weekly, 2.4-milligram (mg) semaglutide injections, such as pancreatitis, acute kidney injury, gallbladder issues, and thyroid cancer.
The FDA (U.S. Food and Drug Administration) suggests taking Cialis at a maximum as-needed dosage of 10 milligrams no more than once per 72 hours — or a daily dosage of 2.5 milligrams — if you ...
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...
Eli Lilly’s experimental insulin that is injected just once a week is as effective as daily insulin injections for maintaining blood sugar levels in patients with type 1 or type 2 diabetes ...