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The drug is occasionally used on an intermittent basis to prevent seizures in catamenial epilepsy. [10] The sulfur-containing antiseizure and antimigraine drug topiramate is a weak inhibitor of carbonic anhydrase, particularly subtypes II and IV. [11] Whether carbonic anhydrase inhibition contributes to its clinical activity is not known.
Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class.Dichlorphenamide as a carbonic anhydrase inhibitor is used for the treatment of acute angle closure glaucoma.
Acetazolamide is a carbonic anhydrase inhibitor, hence causing the accumulation of carbonic acid. [12] Carbonic anhydrase is an enzyme found in red blood cells and many other tissues that catalyses the following reaction: [26] H 2 CO 3 ⇌ H 2 O + CO 2. hence lowering blood pH, by means of the following reaction that carbonic acid undergoes: [27]
For example, carbonic anhydrase produces acid in the stomach lining. In the kidney, the control of bicarbonate ions influences the water content of the cell. The control of bicarbonate ions also influences the water content in the eyes. Inhibitors of carbonic anhydrase are used to treat glaucoma, the excessive build-up of water in the eyes.
Carbonic anhydrase inhibitors (Trusopt, Azopt): This is another medication that reduces fluid production. Side effects include tingling in the fingers and toes, needing to frequently urinate, and ...
Topiramate has many drug-drug interactions. Some of the most common are listed below: As topiramate inhibits carbonic anhydrase, use with other inhibitors of carbonic anhydrase (e.g. acetazolamide) increases the risk of kidney stones. [citation needed]
Brinzolamide (trade name Azopt) is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Brinzolamide was approved as a generic medication in the United States in November 2020. [2]
Carbonic anhydrase inhibitors inhibit the enzyme carbonic anhydrase which is found in the proximal convoluted tubule. This results in several effects including bicarbonate accumulation in the urine and decreased sodium absorption. Drugs in this class include acetazolamide and methazolamide. [citation needed]