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Depressed individuals have a shorter life expectancy than those without depression, in part because people who are depressed are at risk of dying of suicide. [269] About 50% of people who die of suicide have a mood disorder such as major depression, and the risk is especially high if a person has a marked sense of hopelessness or has both ...
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. [ 1 ] Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 2 ]
An estimated 4.4 percent of the global population has depression, according to a report released by the UN World Health Organization (WHO), which shows an 18 percent increase in the number of people living with depression between 2005 and 2015. [66] [67] [68] Depression is a major mental-health cause of disease burden.
Causes: Family history, previous diagnosis of a mood disorder, trauma, stress or major life changes in the case of depression, physical illness or use of certain medications. Depression has been linked to major diseases such as cancer, diabetes, Parkinson's disease and heart disease, Brain structure and function in the case of bipolar disorder. [1]
Depression is a significant mental illness with physiological and psychological consequences, including sluggishness, diminished interest and pleasure, and disturbances in sleep and appetite. [1] It is predicted that by the year 2030, depression will be the number one cause of disability in the United States and other high-income countries. [2]
The cause of depression is believed to be due to a combined effect of genetic and environmental factors. [11] Other medical conditions, for example hypothyroidism, may cause people to experience similar symptoms as a major depressive episode. [20]