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Structure of a BiTE. V H: Heavy chain variable regions. V L: Light chain variable regions. Different specificity is marked with different colours and shapes. The arrows point from N-to C-terminus. Bi-specific T-cell engager (BiTE) is a class of artificial bispecific monoclonal antibodies that are investigated for use as anti-cancer drugs.
Where NICE has approved a treatment, the NHS must fund it. But not all treatments have been assessed by NICE and these treatments are usually dependent on local NHS decision making. In the case of cancer the Cancer Drugs Fund was set up in 2011 after complaints about NICE decisions on new and expensive cancer drugs with limited benefits.
Companion animals, including dogs, cats, rats, ferrets, and parrots, may bite humans. Wildlife may sometimes bite humans. The bites of various mammals such as bats, skunks, wolves, raccoons, etc. may transmit rabies, which is almost always fatal if left untreated. [1] Human bites are themselves capable of doing great flesh damage, but are ...
Animal bites are the most common form of injury from animal attacks. The U.S. estimated annual count of animal bites is 250,000 human bites, 1 to 2 million dog bites, 400,000 cat bites, and 45,000 bites from snakes. [2] Bites from skunks, horses, squirrels, rats, rabbits, pigs, and monkeys may be up to one percent of bite injuries.
Rapid diagnosis and treatment; Recent improvements in malaria prevention strategies have further enhanced its effectiveness in combating areas highly infected with the malaria parasite. Additional bite prevention measures include mosquito and insect repellents that can be directly applied to skin.
A bite is defined as coming from the mouthparts of the arthropod. The bite consists of both the bite wound and the saliva. The saliva of the arthropod may contain anticoagulants, as in insects and arachnids which feed from blood. Feeding bites may also contain anaesthetic, to prevent the bite from being felt.
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Human tetanus immunoglobulin injected intrathecally (which increases clinical improvement from 4% to 35%). Tracheotomy and mechanical ventilation for 3 to 4 weeks. Tracheotomy is recommended for securing the airway, because the presence of an endotracheal tube is a stimulus for spasm.