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Vitamin D deficiency or hypovitaminosis D is a vitamin D ... This is the active form of vitamin D in the body. Kidney disease reduces 1,25 ... to body weight. ...
Vitamin D deficiency can occur. Vitamin D binding protein is lost. Hypocalcaemia: lack of 25-hydroxycholecalciferol (the way that vitamin D is stored in the body). As vitamin D regulates the amount of calcium present in the blood, a decrease in its concentration will lead to a decrease in blood calcium levels. It may be significant enough to ...
Deficiency in Vitamin D or renal disease contributes to bone disorder such as in Osteomalacia in adult and Rickets in children. [2] Osteomalacia is the softening of bones due to poor bone mineralization which is in turn due to poor calcium absorption. [ 2 ]
The conversion of 25(OH) vitamin D to 1,25(OH)2 vitamin D is impaired, reducing intestinal calcium absorption and increasing PTH. [2] The kidney fails to respond adequately to PTH, which normally promotes phosphaturia and calcium reabsorption, or to FGF-23, which also enhances phosphate excretion. [2]
Taking too much vitamin D can be toxic in rare cases, as with an 89-year-old U.K. man who died in March in part from vitamin D toxicity (though he did have several underlying conditions).
Vitamin D (the inactive version) is mainly from two forms: vitamin D 3 and vitamin D 2. Vitamin D 3, or cholecalciferol, is formed in the skin after exposure to sunlight or ultra violet radiation or from D 3 supplements or fortified food sources. Vitamin D 2, or ergocalciferol, is obtained from D 2 supplements or fortified food sources. [3]