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Serious side effects may include seizures, an increased risk of suicide in those less than 25 years of age, urinary retention, glaucoma, mania, and a number of heart issues. [8] Nortriptyline may cause problems if taken during pregnancy. [8] Use during breastfeeding appears to be relatively safe. [7]
The nortriptyline group experienced moderate weight gain. ... SSRI side effects include nausea, dry mouth, upset stomach, intimate dysfunction, insomnia and weight gain or loss.
Its side effects are especially noticeable early in therapy. [6] In most people, early TCA side effects decrease or disappear entirely with time, but, until then, patients taking protriptyline should take care to assess which side effects occur in them and should not perform hazardous activities requiring mental acuity or coordination. [ 8 ]
The side effects of the TCAs usually come to prominence before the therapeutic benefits against depression and/or anxiety do, and for this reason, they may potentially be somewhat dangerous, as volition can be increased, possibly giving the patient a greater desire to attempt or commit suicide.
Tricyclic antidepressants, such as desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor) and protriptyline, and tetracyclic antidepressants, such as mirtazapine (Remeron).
Due to its side effects, amitriptyline isn’t commonly used as a first-line treatment for depression. Viorel Kurnosov/istockphoto Another well-known TCA is doxepin, sold under the name Silenor.
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