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Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate, including those with polycystic ovary syndrome. [5] It is taken by mouth . [ 5 ]
Clomiphene is initiated for use in patients with polycystic ovary syndrome, psychogenic amenorrhea, post-oral contraceptive amenorrhea, and secondary amenorrhea of unidentified cause. [14] Serum estrogen should be measured prior to therapy which rules out primary pituitary or ovarian failure , endometrial carcinoma , hyperprolactinaemia .
Enclomifene (INN Tooltip International Nonproprietary Name), or enclomiphene (USAN Tooltip United States Adopted Name), a nonsteroidal selective estrogen receptor modulator of the triphenylethylene group, acts by antagonizing the estrogen receptor (ER) in the pituitary gland, which reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin ...
These treatments can include selective estrogen receptor modulators like clomiphene , a derivative of clomiphene called enclomiphene, or aromatase inhibitors like anastrozole (Arimidex®). These ...
Clomiphene is a selective estrogen receptor modulator (SERM). [5] It is the most widely used fertility drug. [ 6 ] Other medications in this class include tamoxifen and raloxifene , although both are not as effective as clomiphene and are thus less widely used for fertility purposes. [ 7 ]
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No other insulin sensitizers have evidence of effective and safe use of fertility treatment. [10] Previously, metformin was recommended as treatment for anovulation in polycystic ovary syndrome, but in the largest trial to date, comparing clomiphene with metformin, clomiphene was more effective than metformin alone. [5]