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The ESV Study Bible (abbreviated as the ESVSB [1] [2]) is a study Bible published by Crossway. Using the text of the English Standard Version , the ESVSB features study notes from a perspective of "classic evangelical orthodoxy, in the historic stream of the Reformation ."
In 2009, the Evangelical Christian Publishers Association (ECPA) named the ESV Study Bible as Christian Book of the Year. This was the first time in the award's 30-year history to be given to a study Bible. [34] By September 2024, the ESV Study Bible had sold more than 2.5 million copies. [35]
Keratin 1 is a Type II intermediate filament (IFs) of the intracytoplasmatic cytoskeleton. Is co-expressed with and binds to Keratin 10, a Type I keratin, to form a coiled coil heterotypic keratin chain. Keratin 1 and Keratin 10 are specifically expressed in the spinous and granular layers of the epidermis. [5]
Perhaps the first edition of an English language Bible that qualified as a "study Bible" was the Geneva Bible published by Sir Rowland Hill in 1560; [1] [2] it contained extensive cross-references, synopses, and doctrinal points. The text of the Geneva Bible was usually not printed without the commentary, though the Cambridge edition was ...
This central domain of the chain provides the molecular alignment in the keratin structure and makes the chains form coiled dimers in solution. The end-domain sequences of type I and II cytokeratin chains contain in both sides of the rod domain the subdomains V1 and V2, which have variable size and sequence.
Overall, keratin type 2 plays a crucial role in maintaining the strength and integrity of the skin, hair, and nails. Mutations in keratin genes can lead to various genetic disorders that affect these tissues, such as epidermolysis bullosa simplex, a rare condition characterized by blistering and erosion of the skin and mucous membranes. [3]
In 2005, Ligonier Ministries self-published a minor revision to the Reformation Study Bible, now using the Bible text of the English Standard Version. [2] [3] In 2015, a fully revised version of the Reformation Study Bible was released. The notes were expanded into a three column format and the theological and doctrinal content was updated.
Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene. [5] [6] [7] [8]The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails.