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Cryptorchidism, also known as undescended testis, is the failure of one or both testes to descend into the scrotum. The word is from Ancient Greek ...
The lower part persists as the gubernaculum testis ("scrotal ligament"). This ligament secures the testis to the most inferior portion of the scrotum, tethering it in place and limiting the degree to which the testis can move within the scrotum. Cryptorchidism (undescended testes) are observed in INSL3-null male mice.
The ectopic testis can be in the perineal region, the opposite side of the scrotum, the suprapubic region, the femoral region, or the superficial inguinal pouch. [1]The ectopic testis is initially normal, but if it is ignored after childhood, it may become small and soft, with spermatogenesis arresting and interstitial cell proliferation occurring.
In this case the testis is within the abdominal cavity, somewhere along the normal route of descent – most commonly, within the inguinal canal. Such a testis has an increased risk of malignancy. One testicle may disappear during development (the so-called vanishing testis) due to some intrauterine insult.
The undescended testis is at increased risk of testicular torsion. [17] The mechanism for torsion in the undescended testicle is not fully understood, though it may be due to abnormal contractions of the cremaster muscle, which covers the testicle and spermatic cord and is responsible for raising and lowering the testicle to regulate scrotal ...
The most common presentation of testicular cancer is a hard, painless lump which can be felt on one of the testis. It is either noticed by a clinician during a routine examination, or the patient themselves. [17] Risk factors for TC include: Cryptorchidism; Family history; Previous testicular cancer; The diagnosis is confirmed in different ways.
testicular microlithiasis on ultrasound. Testicular microlithiasis is an unusual condition diagnosed on testicular ultrasound. It is believed to be found in 0.1–0.6% of males globally, with frequency varying based on geographic location and is more often found in individuals with subfertility.
FMRP is made from the FMR1 gene and is mainly in the brain and testis. They used the analysis of covariance (ANCOVA) to compare the IQs of the macroorchidism patients with and without pre-mutation carriers. The results showed that there is a relationship between macroorchidism and intellectual disability in FMR1 pre-mutation carrier males.