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Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2] It contains lisinopril , an ACE inhibitor , and hydrochlorothiazide , a diuretic .
The price paid by pharmacists and doctors is determined mainly by the number of license holders, the sales value of the original brand, and the ease of manufacture. A typical price decay graph will show a "scalloped" curve, [25] which usually starts at the brand-name price on the day of generic launch and then falls as competition intensifies ...
Patented Medicine Prices Review Board office in Ottawa. Bill C-22, which was passed in 1987, established a compulsory licensing system under which drug patent holders were required to allow competing drug manufacturers to import their patented drug in exchange for a very modest 4% royalty, which resulted in an increase in the market share of generic drugs.
A streetcar used by Royal Mail Canada in Ottawa, c. 1890s It was in 1867 that the newly formed Dominion of Canada created the Post Office Department as a federal government department (The Act for the Regulation of the Postal Service) headed by a Cabinet minister, the Postmaster General of Canada.
Lisinopril works by inhibiting the renin–angiotensin–aldosterone system. [7] Lisinopril was patented in 1978 and approved for medical use in the United States in 1987. [7] [11] It is available as a generic medication. [7] In 2022, it was the third most commonly prescribed medication in the United States, with more than 82 million prescriptions.
The service became quickly popular: for UPS the number of packages tracked on the web increased from 600 a day in 1995 [9] to 3.3 million a day in 1999. [10] On-line package tracking became available for all major carrier companies, and was improved by the emergence of websites that offered consolidated tracking for different mail carriers. [11]
Prescription drug list prices in the United States continually are among the highest in the world. [1] [2] The high cost of prescription drugs became a major topic of discussion in the 21st century, leading up to the American health care reform debate of 2009, and received renewed attention in 2015.
In November 2016, India's Drug Consultative Committee announced it was embarking on establishing a definition of drugs which could be dispensed without a prescription. [1] Prior to this, the general assumption was that any drug which did not fall into a prescription schedule could be purchased without a prescription. [ 1 ]