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Hence, GWAS is a non-candidate-driven approach, in contrast to gene-specific candidate-driven studies. GWA studies identify SNPs and other variants in DNA associated with a disease, but they cannot on their own specify which genes are causal. [1] [2] [3] The first successful GWAS published in 2002 studied myocardial infarction. [4]
The method was first described by Elshire et al. (2011). [1] In summary, high molecular weight DNAs are extracted and digested using a specific RE previously defined by cutting frequently [7] in the major repetitive fraction of the genome. ApeKI is the most used RE. Barcode adapters are then ligated to sticky ends and PCR amplification is ...
A genome-wide association study, or GWAS, is a genetic tool that uses single nucleotide polymorphisms, or SNPs, to identify if a trait or disease is linked to a specific genetic variant. By observing if frequencies of a specific variant are more commonly associated, or higher than expected, with the given trait; an association is developed ...
GWAS Central is a core component of the GEN2PHEN project and intends to provide an operational model, plus an open-source software package, so others can create similar databases across the world. These will be hosted by institutes, consortia, and even individual laboratories; providing those groups a toolkit for publicising and publishing ...
Hindi has drawn increasing focus as an academic subject. [8] There is a growing trend of Hindi experts and the availability of texts in Pakistan. [8] Many Hindi instructors migrated from India, or were educated at Indian universities. [5] The Department of Hindi at the National University of Modern Languages (NUML) in Islamabad was
Hindustani, the lingua franca of Northern India and Pakistan, has two standardised registers: Hindi and Urdu.Grammatical differences between the two standards are minor but each uses its own script: Hindi uses Devanagari while Urdu uses an extended form of the Perso-Arabic script, typically in the Nastaʿlīq style.
An editorial in Pakistan's oldest newspaper Dawn, commenting on a report in The Guardian on Pakistani Textbooks, noted 'By propagating concepts such as jihad, the inferiority of non-Muslims, India's ingrained enmity with Pakistan, etc., the textbook board publications used by all government schools promote a mindset that is bigoted and ...
In terms of technology, Pakistan has made significant strides in nuclear physics and explosives engineering, primarily driven by security concerns. The country is also involved in space exploration, with a focus on military applications. Pakistan is an associate member of CERN, a prestigious international research organization. [2]