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Hence, GWAS is a non-candidate-driven approach, in contrast to gene-specific candidate-driven studies. GWA studies identify SNPs and other variants in DNA associated with a disease, but they cannot on their own specify which genes are causal. [1] [2] [3] The first successful GWAS published in 2002 studied myocardial infarction. [4]
In the field of genetic sequencing, genotyping by sequencing, also called GBS, is a method to discover single nucleotide polymorphisms (SNP) in order to perform genotyping studies, such as genome-wide association studies . [1] GBS uses restriction enzymes to reduce genome complexity and genotype multiple DNA samples. [2]
GWAS Central is a core component of the GEN2PHEN project and intends to provide an operational model, plus an open-source software package, so others can create similar databases across the world. These will be hosted by institutes, consortia, and even individual laboratories; providing those groups a toolkit for publicising and publishing ...
The most commonly accepted threshold is p < 5 × 10 −8, which is based on performing a Bonferroni correction for all the independent common SNPs across the human genome. [1] If a p-value is found to be lower than this threshold in a genome-wide association study, the null hypothesis of no true SNP-association will typically be rejected. [2]
A genome-wide association study, or GWAS, is a genetic tool that uses single nucleotide polymorphisms, or SNPs, to identify if a trait or disease is linked to a specific genetic variant. By observing if frequencies of a specific variant are more commonly associated, or higher than expected, with the given trait; an association is developed ...
[1] The ordeals of partition and the migration also adversely affected Abdul Haq's health. [citation needed] He re-organised the Anjuman Taraqqi-e-Urdu in Karachi, launching journals, establishing libraries and schools, publishing a large number of books and promoting education in the Urdu language and linguistic research in it. [5]
Hindi has drawn increasing focus as an academic subject. [8] There is a growing trend of Hindi experts and the availability of texts in Pakistan. [8] Many Hindi instructors migrated from India, or were educated at Indian universities. [5] The Department of Hindi at the National University of Modern Languages (NUML) in Islamabad was
An editorial in Pakistan's oldest newspaper Dawn, commenting on a report in The Guardian on Pakistani Textbooks, noted 'By propagating concepts such as jihad, the inferiority of non-Muslims, India's ingrained enmity with Pakistan, etc., the textbook board publications used by all government schools promote a mindset that is bigoted and ...