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Difethialone is an anticoagulant used as a rodenticide. [1] It is considered a second generation agent. [2] In May 2008, the EPA added restrictions on the sale of difethialone in consumer-use rodenticide products and also for exterior use by commercial applicators. [3] [4]
Insecticides, larvicides, rodenticides, Lethal ovitraps and repellents can be used to control vectors. For example, larvicides can be used in mosquito breeding zones; insecticides can be applied to house walls or bed nets, and use of personal repellents can reduce incidence of insect bites and thus infection.
Diphenadione is a vitamin K antagonist that has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other rodents. The chemical compound is an anti-coagulant with active half-life longer than warfarin and other synthetic 1,3-indandione anticoagulants.
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It is a second generation (i.e., high potency) chemical in this class, used commercially as a rodenticide. It has a very high toxicity and is restricted to indoor use and sewers (in the UK). This restriction is mainly due to the increased risk to non-target species, especially due to its tendency to bio-accumulate in exposed organisms.
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Chlorophacinone is a first-generation anticoagulant rodenticide.The mechanism of action results in internal bleeding due to non-functional clotting factors. It was used as a toxin to control rodent populations.