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Sodium citrate saline is one of the most effective osmotic laxatives (secondary in action only to magnesium citrate). [8] Its laxative action is the result of osmotic imbalance that extracts bound water from stool and pulls it back into the large bowel. The increased water content softens the stool and stimulates the bowel to contract (move its ...
It acts primarily as a stool lubricant, and is thus not associated with abdominal cramps, diarrhea, flatulence, disturbances in electrolytes, or tolerance over long periods of usage, side effects that osmotic and stimulant laxatives often engender (however, some literature suggests that these may still occur).
[5] [6] This compound is a stimulant laxative and increases peristalsis in the gut. [5] [7] Sodium picosulfate is typically prescribed in a combined formulation with magnesium citrate, an osmotic laxative. This combination is a highly effective laxative, often prescribed to patients for bowel cleansing prior to colonoscopies. [5] [8]
Macrogol 4000, pharmaceutical quality. Macrogol 3350, often in combination with electrolytes, is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in multiple sclerosis and Parkinson's disease patients (an often-overlooked non-motor symptom) as well as constipation caused by pharmaceutical drugs such as opioids and ...
For example, severe hypokalaemia has been associated with distal renal tubular acidosis from laxative abuse. [26] Metabolic alkalosis is the most common acid-base imbalance observed. [ 26 ] Other significant adverse effects include rhabdomyolysis , [ 26 ] steatorrhoea , [ 26 ] inflammation and ulceration of colonic mucosa, [ 26 ] pancreatitis ...
Osmotic laxatives: Products such as Miralax (polyethylene glycol) pull water from other parts of the body and into the colon. This extra water adds volume and pressure, which can make it easier to ...
Sodium citrate is used to relieve discomfort in urinary-tract infections, such as cystitis, to reduce the acidosis seen in distal renal tubular acidosis, and can also be used as an osmotic laxative. It is a major component of the WHO oral rehydration solution .
Mannitol acts as an osmotic laxative [3] [20] in oral doses larger than 20 g, [21] and is sometimes sold as a laxative for children. [citation needed] The use of mannitol, when inhaled, as a bronchial irritant as an alternative method of diagnosis of exercise-induced asthma has been proposed. A 2013 systematic review concluded evidence to ...