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Fluorine-18 (18 F, also called radiofluorine) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 96.7% of the time and electron capture 3.3% of the time.
For this reason 18 F is a commercially important source of positrons. Its major value is in the production of the radiopharmaceutical fludeoxyglucose, used in positron emission tomography in medicine. Fluorine-18 is the lightest unstable nuclide with equal odd numbers of protons and neutrons, having 9 of each.
F and 18 F undergo β + decay and electron capture, lighter isotopes decay by proton emission, and those heavier than 19 F undergo β − decay (the heaviest ones with delayed neutron emission). [54] [55] Two metastable isomers of fluorine are known, 18m F, with a half-life of 162(7) nanoseconds, and 26m F, with a half-life of 2.2(1 ...
Flurpiridaz F-18 is a fluorine 18-labeled agent developed by Lantheus Medical Imaging for the diagnosis of coronary artery disease. [7]The efficacy and safety of flurpiridaz (18 F) were evaluated in two prospective, multicenter, open-label clinical studies in adults with either suspected CAD (Study 1: NCT03354273) or known or suspected CAD (Study 2: NCT01347710). [3]
The usefulness of fluorine-containing radiopharmaceuticals in 18 F-positron emission tomography has motivated the development of new methods for forming C–F bonds. Because of the short half-life of 18 F, these syntheses must be highly efficient, rapid, and easy. [25]
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Sodium fluoride is an inorganic ionic compound, dissolving in water to give separated Na + and F − ions. Like sodium chloride, it crystallizes in a cubic motif where both Na + and F − occupy octahedral coordination sites; [33] [34] its lattice spacing, approximately 462 pm, is smaller than that of sodium chloride (564 pm).
Fluorodopa, also known as FDOPA, is a fluorinated form of L-DOPA primarily synthesized as its fluorine-18 isotopologue for use as a radiotracer in positron emission tomography (PET). [ 1 ] The most common side effects are injection site pain.