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The proportion of AST to ALT in hepatocytes is about 2.5:1, but because AST is removed from serum by the liver sinusoidal cells twice as quickly (serum half-life t 1/2 = 18 hr) compared to ALT (t 1/2 = 36 hr), so the resulting serum levels of AST and ALT are about equal in healthy individuals, resulting in a normal AST/ALT ratio around 1.
In alcoholic liver disease, the mean ratio is 1.45, and mean ratio is 1.33 in post necrotic liver cirrhosis. Ratio is greater than 1.17 in viral cirrhosis, greater than 2.0 in alcoholic hepatitis, and 0.9 in non-alcoholic hepatitis. Ratio is greater than 4.5 in Wilson disease or hyperthyroidism. [6]
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Cirrhosis is more common in men than in women. [158] The cost of cirrhosis in terms of human suffering, hospital costs, and lost productivity is high. Globally, age-standardized disability-adjusted life year (DALY) rates have decreased from 1990 to 2017, with the values going from 656.4 years per 100,000 people to 510.7 years per 100,000 people ...
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AST/ALT ratio in context of other factors such as absolute values and other markers [ edit ] The article discusses the ratio of AST/ALT without reference to the absolute values or other markers that would be used as part of the interpretation of the ratio. e.g. AST=20, ALT=10 IU/L, Bilirubin = 0.8 mg/dl; vs AST=200, ALT = 100, Bilirubin = 1.5.
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A woman got a breast exam on live TV. No bra, no carefully draped gown, no blurring. On the British talk show This Morning, model Leeanne Adu, who wears a size 38JJ bra, disrobed and had Dr. Sara ...