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Capsules allow adhesion to surfaces and help enable the bacteria to evade the host immune system. [6] The water content in the capsule gives the protection against drying out. The capsule is considered a virulence factor because it enhances the ability of bacteria to cause disease (e.g. prevents phagocytosis).
Examples of virulence factors for Staphylococcus aureus are hyaluronidase, protease, coagulase, lipases, deoxyribonucleases and enterotoxins. Examples for Streptococcus pyogenes are M protein , lipoteichoic acid , hyaluronic acid capsule, destructive enzymes (including streptokinase , streptodornase , and hyaluronidase ), and exotoxins ...
S. pyogenes has several virulence factors that enable it to attach to host tissues, evade the immune response, and spread by penetrating host tissue layers. [18] A carbohydrate-based bacterial capsule composed of hyaluronic acid surrounds the bacterium, protecting it from phagocytosis by neutrophils. [2]
Virulence is a pathogen's or microorganism's ability to cause damage to a host. In most cases, especially in animal systems, virulence refers to the degree of damage caused by a microbe to its host. [1] The pathogenicity of an organism—its ability to cause disease—is determined by its virulence factors.
Invasins, such as pneumolysin, an antiphagocytic capsule, various adhesins, and immunogenic cell wall components are all major virulence factors. After S. pneumoniae colonizes the air sacs of the lungs, the body responds by stimulating the inflammatory response, causing plasma, blood, and white blood cells to fill the alveoli. This condition is ...
The C. neoformans capsule consists of several polysaccharides, of which the major one is the immunomodulatory polysaccharide called glucuronoxylomannan (GXM). [4] GXM is made up of the monosaccharides glucuronic acid, xylose and mannose and can also contain O-acetyl groups. The capsule functions as the major virulence factor in cryptococcal ...
P. multocida expresses a range of virulence factors including a polysaccharide capsule and the variable carbohydrate surface molecule, lipopolysaccharide (LPS). The capsule has been shown in strains of serogroups A and B to help resist phagocytosis by host immune cells and capsule type A has also been shown to help resist complement-mediated lysis.
Staphylococcus aureus is a pathogenic bacteria that causes several human infections with a plethora of virulence factors such as: biofilm formation, quorum sensing, and exotoxins to name a few. [13] Researchers took a look at Myricetin (Myr) as a multi-anti-virulence agent against S.areus and how it specifically impacts biofilm formation. After ...