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340061 72512 Ensembl ENSG00000184584 ENSG00000288243 ENSMUSG00000024349 UniProt Q86WV6 Q3TBT3 RefSeq (mRNA) NM_001301738 NM_198282 NM_001367258 NM_001289591 NM_001289592 NM_028261 RefSeq (protein) NP_001288667 NP_938023 NP_001354187 NP_001276520 NP_001276521 NP_082537 Location (UCSC) Chr 5: 139.48 – 139.48 Mb Chr 18: 35.87 – 35.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ...
Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). [1] Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. [2]
Index inducer or just inducer predictably induce metabolism via a given pathway and are commonly used in prospective clinical drug-drug interaction studies. [2]Strong, moderate, and weak inducers are drugs that decreases the AUC of sensitive index substrates of a given metabolic pathway by ≥80%, ≥50% to <80%, and ≥20% to <50%, respectively.
Gene regulation works using operators and repressors in bacteria. Gene Regulation can be summarized by the response of the respective system: Inducible systems - An inducible system is off unless there is the presence of some molecule (called an inducer) that allows for gene expression. The molecule is said to "induce expression".
Activator binds to an inducer and the complex binds to the activation sequence and activates target gene. [2] Removing the inducer stops transcription. [2] Because a small inducer molecule is required, the increased expression of the target gene is called induction. [2] The lactose operon is one example of an inducible system. [2]
Moderate inhibitor being one that causes at least a 2-fold increase in the plasma AUC values of sensitive substrates metabolized through CYP1A2, or 50-80% decrease in clearance thereof. [ 18 ] Weak inhibitor being one that causes at least a 1.25-fold but less than 2-fold increase in the plasma AUC values of sensitive substrates metabolized ...
IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. [8] [9] In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40.
WNT1-inducible-signaling pathway protein 1 (WISP-1), [5] is a member of the CCN protein family and should correctly be referred to as CCN4 as suggested by the International CCN Society. [6] It is a matricellular protein that in humans is encoded by the WISP1 gene .