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In addition to tremors, lithium treatment appears to be a risk factor for development of parkinsonism-like symptoms, although the causal mechanism remains unknown. [73] In the average bipolar patient, chronic lithium use is not associated with cognitive decline. [74] Most side effects of lithium are dose-dependent.
Potential side effects from lithium include gastrointestinal upset, tremor, sedation, excessive thirst, frequent urination, cognitive problems, impaired motor coordination, hair loss, and acne. [3] Excessive levels of lithium can be harmful to the kidneys, and increase the risk of side effects in general.
Bipolar disorder is a long-term mood disorder characterized by major fluctuations in mood — both high and low — that can impact daily functioning and behavior. Bipolar Disorder: 4 Types & What ...
Lithium is preferred for long-term mood stabilization. [68] Lithium treatment is also associated with adverse effects and it has been shown to erode kidney and thyroid function over extended periods. [17] Valproate has become a commonly prescribed treatment and effectively treats manic episodes. [147]
Medications are used to reverse the symptoms of extrapyramidal side effects caused by antipsychotics or other drugs, by either directly or indirectly increasing dopaminergic neurotransmission. The treatment varies by the type of the EPS, but may involve anticholinergic agents such as procyclidine, benztropine, diphenhydramine, and trihexyphenidyl.
Taking lithium salts has risks and side effects. Extended use of lithium to treat mental disorders has been known to lead to acquired nephrogenic diabetes insipidus. [16] Lithium intoxication can affect the central nervous system and renal system and can be lethal. [17]
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