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The myosin-binding protein C, cardiac-type is a protein that in humans is encoded by the MYBPC3 gene. [5] This isoform is expressed exclusively in heart muscle during human and mouse development, [6] and is distinct from those expressed in slow skeletal muscle and fast skeletal muscle ().
In the thick myofilaments of the heart tissue, the predominant gene mutations occur in “myosin-binding protein C (MYBPC3)” and “myosin heavy chain (MYH7).” Myocardial infarction, atrial fibrillation, ventricular fibrillation, embolic events, and/or congestive heart failure are all possible outcomes of this condition.
Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood effectively. [3] Symptoms vary from none to feeling tired, leg swelling, and shortness of breath. [2] It may also result in chest pain or fainting. [2] Complications can include heart failure, heart valve disease, or an irregular heartbeat. [3] [4]
The two main myofilaments in cardiac (and skeletal) muscle are actin and myosin. Ca 2+ binds to a protein called troponin, which is bound to the actin filament. This binding causes a shape change in the troponin which exposes areas on the actin, to which the head of the myosin filament binds. The binding of the myosin head to actin is known as ...
4606 233199 Ensembl ENSG00000086967 ENSMUSG00000038670 UniProt Q14324 Q5XKE0 RefSeq (mRNA) NM_004533 NM_146189 RefSeq (protein) NP_004524 NP_666301 Location (UCSC) Chr 19: 50.43 – 50.47 Mb Chr 7: 44.15 – 44.17 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myosin binding protein C, fast type is a protein that in humans is encoded by the MYBPC2 gene. Function This gene encodes a ...
When calcium becomes bound to specific sites in the N-domain of TnC, a series of protein structural changes occurs, [citation needed] such that tropomyosin is rolled away from myosin-binding sites on actin, allowing myosin to attach to the thin filament and produce force and shorten the sarcomere. [citation needed]
These high-protein casseroles, like chicken florentine and tamari-ginger meatballs, are low in sodium and saturated fat for a heart-healthy dinner. 18 High-Protein Casseroles For Better Heart ...
The disease is a type of non-ischemic cardiomyopathy that primarily involves the right ventricle, though cases of exclusive left ventricular disease have been reported. It is characterized by hypokinetic areas involving the free wall of the ventricle, with fibrofatty replacement of the myocardium, with associated arrhythmias often originating ...