Ads
related to: myosin binding protein c heart failure- Heart Failure Symptoms
Access a Free Treatment Guide.
Understand Heart Failure Symptoms.
- Heart Failure Stages
Access Our Heart Failure Guide.
Learn About Heart Failure Stages.
- Heart Failure in Seniors
Free Heart Failure Treatment Guide.
Understand Heart Failure in Seniors
- Living With Heart Failure
Access a Heart Failure Guide.
Learn About Treatment Options.
- LVAD Treatment
Free Heart Failure Treatment Guide.
Learn About LVAD Treatment Options.
- Heart Failure Treatment
Download Our Free Treatment Guide.
Discover Options for Heart Failure.
- Heart Failure Symptoms
Search results
Results From The WOW.Com Content Network
The myosin-binding protein C, cardiac-type is a protein that in humans is encoded by the MYBPC3 gene. [5] This isoform is expressed exclusively in heart muscle during human and mouse development, [6] and is distinct from those expressed in slow skeletal muscle and fast skeletal muscle ().
In the thick myofilaments of the heart tissue, the predominant gene mutations occur in “myosin-binding protein C (MYBPC3)” and “myosin heavy chain (MYH7).” Myocardial infarction, atrial fibrillation, ventricular fibrillation, embolic events, and/or congestive heart failure are all possible outcomes of this condition.
Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood effectively. [3] Symptoms vary from none to feeling tired, leg swelling, and shortness of breath. [2] It may also result in chest pain or fainting. [2] Complications can include heart failure, heart valve disease, or an irregular heartbeat. [3] [4]
Persistent afterload triggers oxidative stress, activating calcium/calmodulin-dependent protein kinase II. [14] Myosin light chain 2 and cardiac myosin-binding protein C are phosphorylated, strengthening myosin-actin cross-bridge formation and prolonging systolic ejection time to maintain stroke volume. [3] [4]
This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform.
MHC-β is a 223 kDa protein composed of 1935 amino acids. [7] [8] MHC-β is a hexameric, asymmetric motor forming the bulk of the thick filament in cardiac muscle.MHC-β is composed of N-terminal globular heads (20 nm) that project laterally, and alpha helical tails (130 nm) that dimerize and multimerize into a coiled-coil motif to form the light meromyosin (LMM), thick filament rod. [9]
Ad
related to: myosin binding protein c heart failure