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Early monociliated ependymal cells are differentiated to multiciliated ependymal cells for their function in circulating cerebrospinal fluid. [3] The basal membranes of these cells are characterized by tentacle-like extensions that attach to astrocytes. The apical side is covered in cilia and microvilli. [4]
Other cellular extensions that protrude from the cell membrane are known as membrane protrusions or cell protrusions, also cell appendages, such as flagella, and microvilli. [ 8 ] [ 9 ] Microtentacles are cell protrusions attached to free-floating cells, associated with the spread of some cancer cells .
Tanycytes are highly specialized ependymal cells found in the third ventricle of the brain, and on the floor of the fourth ventricle. Each tanycyte has a long basal process that extends deep into the hypothalamus. It is possible that their function is to transfer chemical signals from the cerebrospinal fluid to the central nervous system.
Ependymal cells secrete high molecular mass glycoproteins into the cerebrospinal fluid, in which the bulk of them condense to form a filamentous structure named Reissner's fiber. [4] The subcommissural organ/ Reissner's fiber complex is thought to be involved in the reabsorption and circulation of the cerebrospinal fluid, and with functions ...
Regions of the choroid plexus produce and secrete most of the cerebrospinal fluid (CSF) of the central nervous system. [2] [3] The choroid plexus consists of modified ependymal cells surrounding a core of capillaries and loose connective tissue. [3] Multiple cilia on the ependymal cells move to circulate the cerebrospinal fluid. [4]
Motile cilia are found in large numbers on respiratory epithelial cells – around 200 cilia per cell, where they function in mucociliary clearance, and also have mechanosensory and chemosensory functions. [12] [13] [14] Motile cilia on ependymal cells move the cerebrospinal fluid through the ventricular system of the brain.
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Basal cells are the stem cells or progenitors of the airway epithelium and can differentiate to replenish all of the epithelial cells including the ciliated cells, and secretory goblet cells. [2] [3] This repairs the protective functions of the epithelial barrier. [3] Basal cells are cuboidal with a large nucleus, few organelles, and scattered ...