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A promegakaryocyte is a precursor cell for a megakaryocyte, the development of which proceeds as follows: [1] CFU-Meg ( hematopoietic stem cell /hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte
In general, megakaryocytes are 10 to 15 times larger than a typical red blood cell, averaging 50–100 μm in diameter. During its maturation, the megakaryocyte grows in size and replicates its DNA without cytokinesis in a process called endomitosis. As a result, the nucleus of the megakaryocyte can become very large and lobulated, which, under ...
The megakaryoblast has a high nucleus to cytoplasm ratio with a nucleus that may be 3 to 5 times the size of the cytoplasm. The nucleus is generally oval, kidney shaped or lobed. Several nucleoli are visible, along with loose chromatin. [10] The chromatin may vary from cell to cell, ranging from fine to heavy and dense.
Genome size ranges (in base pairs) of various life forms. Genome size is the total amount of DNA contained within one copy of a single complete genome.It is typically measured in terms of mass in picograms (trillionths or 10 −12 of a gram, abbreviated pg) or less frequently in daltons, or as the total number of nucleotide base pairs, usually in megabases (millions of base pairs, abbreviated ...
Hematopoiesis: MEP differentiates into megakaryocytes and erythrocytes. Megakaryocyte–erythroid progenitor cells (MEPs), among other blood cells, are generated as a result of hematopoiesis, which occurs in the bone marrow.
[1]. Thrombopoiesis is the formation of thrombocytes (blood platelets) in the bone marrow. Thrombopoietin is the main regulator of thrombopoiesis. Thrombopoietin affects most aspects of the production of platelets.
Two myeloblasts with Auer rods. In cell biology, precursor cells—also called blast cells—are partially differentiated, or intermediate, and are sometimes referred to as progenitor cells.
A comprehensive diagram of human hematopoiesis. Granulopoiesis consists of 5 stages, in which the myeloblast is the first recognizable cell. Next in the differentiation sequence is the monoblast and the promyelocyte, which can develop into one of three different precursor cells: the neutrophilic, basophilic or eosinophilic myelocyte.