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The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein.
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB.
Retinoblastoma protein (pRb). pRb was the first tumor-suppressor protein discovered in human retinoblastoma ; however, recent evidence has also implicated pRb as a tumor-survival factor. RB1 gene is a gatekeeper gene that blocks cell proliferation, regulates cell division and cell death. [ 8 ]
Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.
Retinoblastoma (Rb) is a cancer of the eye due to a mutant pRb protein. [7] When pRb is mutated it becomes nonfunctional and is not able to inhibit the expression of transcription factor E2F. Therefore, E2F is always active and driving the cell cycle to progress from G1 to S phase.
A number of hydrogen bonds also stabilize the TAg–pRb complex. [11] For example, the side chain of Glu-107 forms hydrogen bonds by accepting hydrogens from the main chain amide groups of Phe-721 and Lys-722 in pRb. [11] The mutation of Glu-107 to Lys-107 is expected to result in loss of these hydrogen bonds. [11]
Retinoblastoma protein, pRb, an important tumour-suppressor gene in retinoblastoma; Progesterone receptor B; Other uses ... Permeable reactive barrier, ...