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  2. Carbidopa/levodopa/entacapone - Wikipedia

    en.wikipedia.org/wiki/Carbidopa/levodopa/entacapone

    Levodopa is the immediate precursor to dopamine. Entacapone is a selective, reversible catechol-O-methyltransferase (COMT) inhibitor that prevents the degradation of levodopa.

  3. Carbidopa/levodopa - Wikipedia

    en.wikipedia.org/wiki/Carbidopa/levodopa

    Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa. [6] It is primarily used to manage the symptoms of Parkinson's disease, but it does not slow down the disease or stop it from getting worse. [6] It is taken by mouth. [6]

  4. Entacapone - Wikipedia

    en.wikipedia.org/wiki/Entacapone

    Entacapone together with levodopa and carbidopa allows levodopa to have a longer effect in the brain and reduces Parkinson's disease signs and symptoms for a greater length of time than levodopa and carbidopa therapy alone. [2] Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). [2] When taken ...

  5. Management of Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Management_of_Parkinson's...

    Stalevo, a commercial preparation combining entacapone, levodopa, and carbidopa for treatment of Parkinson's disease Circuits of the basal ganglia in treatment of Parkinson's disease – model of the effect of medication on motor symptoms: levodopa, dopamine agonists and MAO-B inhibitors stimulate excitatory signals from the thalamus to the ...

  6. Catechol-O-methyltransferase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Catechol-O-methyltransfer...

    COMT inhibitors are indicated for the treatment of Parkinson's disease in combination with levodopa and an aromatic L-amino acid decarboxylase inhibitor (e.g. carbidopa or benserazide). The therapeutic benefit of using a COMT inhibitor is based on its ability to prevent the methylation of levodopa to 3- O -methyldopa , thus increasing the ...

  7. Carbidopa - Wikipedia

    en.wikipedia.org/wiki/Carbidopa

    Carbidopa (Lodosyn) is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism of levodopa.This property is significant in that it allows a greater proportion of administered levodopa to cross the blood–brain barrier for central nervous system effect, instead of being peripherally metabolised into substances unable to cross said barrier.

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