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Almost any form of substance may be amenable to sublingual administration if it dissolves easily in saliva. Powders and aerosols may all take advantage of this method. However, a number of factors, such as pH, molecular weight, and lipid solubility, may determine whether the route is practical. Based on these properties, a suitably soluble drug ...
Studies have shown that tolerance can play a role in how quickly you return to baseline. So infrequent users can be very much impaired by a low dose, while a daily user might have less adverse ...
Low levels can be detected in the brain, testes, and unborn fetuses, all of which are protected from systemic circulation via barriers. [61] THC further distributes into fatty tissues a few days after administration due to its high lipophilicity, and is found deposited in the spleen and fat after redistribution.
Likewise better controlled studies have found lower (or no) elevated crash risk estimates". [10] The study found that "after adjusting for age, gender, race and alcohol use, drivers who tested positive for marijuana were no more likely to crash than those who had not used any drugs or alcohol prior to driving". [ 3 ]
CBD is a very low-affinity CB 1 ligand, that can nevertheless affect CB 1 receptor activity in vivo in an indirect manner, while THCV is a high-affinity CB 1 receptor ligand and potent antagonist in vitro and yet only occasionally produces effects in vivo resulting from CB 1 receptor antagonism.
Ingesting cannabis may produce effects that last longer and can be more intense than inhaling cannabis. [2] [3] Different edible formats of cannabinoids may affect the rate of cannabinoid digestion and metabolism, which vary among people. [2] [23] [24] Generally, edible cannabis products are digested more slowly than occurs for aerosol products ...
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A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.