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  2. Huntington's disease - Wikipedia

    en.wikipedia.org/wiki/Huntington's_disease

    Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease [7] that is mostly inherited. [8] The earliest symptoms are often subtle problems with mood or mental/psychiatric abilities. [9] [1] A general lack of coordination and an unsteady gait often follow. [2]

  3. Tetrabenazine - Wikipedia

    en.wikipedia.org/wiki/Tetrabenazine

    Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders.It is sold under the brand names Nitoman and Xenazine among others. On August 15, 2008, the U.S. Food and Drug Administration approved the use of tetrabenazine to treat chorea associated with Huntington's disease.

  4. Raphael M. Bonelli - Wikipedia

    en.wikipedia.org/wiki/Raphael_M._Bonelli

    His scientific interest is dementia, especially Huntington's disease. [2] [3] With his neuropsychiatric research group he described eight new treatment options for this disease: Pramipexol, [4] Quetiapine, [5] Minocycline, [6] [7] Mirtazapine, [8] Zotepine, [9] Ziprasidone, [10] Venlafaxine [11] and antipsychotic drug holidays in Huntington's ...

  5. Branaplam - Wikipedia

    en.wikipedia.org/wiki/Branaplam

    Branaplam (development codes LMI070 and NVS-SM1) is a pyridazine derivative that is being studied as an experimental drug.It was originally developed by Novartis to treat spinal muscular atrophy (SMA); since 2020 it was being developed to treat Huntington's disease but the trial ended in 2023 due to toxicity concerns.

  6. Neurodegenerative disease - Wikipedia

    en.wikipedia.org/wiki/Neurodegenerative_disease

    Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system atrophy, tauopathies, and prion diseases. Neurodegeneration can be found in the brain at many different levels of neuronal circuitry, ranging from molecular to systemic. [4]

  7. AB-1001 - Wikipedia

    en.wikipedia.org/wiki/AB-1001

    AB-1001 is an experimental gene therapy developed for Huntington's disease. It is intended to increase the production of the CYP46A1 enzyme and cholesterol levels in the brain. [ 1 ] [ 2 ]

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