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While numerous challenges exist in translating biomarker research into the clinical space; a number of gene and protein based biomarkers have already been used at some point in patient care; including, AFP (liver cancer), BCR-ABL (chronic myeloid leukemia), BRCA1 / BRCA2 (breast/ovarian cancer), BRAF V600E (melanoma/colorectal cancer), CA-125 ...
She created a breast cancer biomarker discovery program that demonstrated the association between hormones, lifestyle factors, and cancer risk. [ 2 ] [ 5 ] Her research demonstrated that women who used hormone replacement therapy were more likely to suffer from breast cancer than women who did not, and that the risk was highest amongst women ...
The following year, she was elected a Fellow of the American Association for the Advancement of Science for "landmark studies of mechanisms, novel therapies and biomarkers, and management of patients with inflammatory breast cancers and women at increased risk for cancers in the United States and Africa."
Breast cancer is the most common cancer in women worldwide, and can, rarely, also occur in men. There are many different types of breast cancer, of which triple-negative breast cancer is one of ...
breast cancer [9] CA27.29: breast cancer [10] CA19-9: Mainly pancreatic cancer, but also colorectal cancer and other types of gastrointestinal cancer. [11] CA-125: Mainly ovarian cancer, [12] but may also be elevated in for example endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer. [13] Calcitonin
One example of a prognostic biomarkers in clinical research, is the use of mutated PIK3CA in the study of metastatic breast cancer. As illustrated by the graph, the mutation is prognostic since its presence in the patient endure the same outcome regardless of the treatment method used. Women who had the PIK3CA mutation before treatment, had the ...
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