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Tolnaftate [1] sold under the brand name TAGRID among, others is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol . [ 2 ]
Topical antifungal drugs are used to treat fungal infections on the skin, scalp, nails, vagina or inside the mouth. These medications come as creams, gels, lotions, ointments , powders, shampoos, tinctures and sprays.
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Antifungal resistance is a One Health concern, driven by multiple extrinsic factors, including extensive fungicidal use, overuse of clinical antifungals, environmental change and host factors. [ 1 ] Like resistance to antibacterials, antifungal resistance can be driven by antifungal use in agriculture.
It is sprayed on plants as a preventive treatment; its mode of action is ineffective after a fungus has become established. It was invented in the Bordeaux region of France in the late 19th century. If it is applied in large quantities annually for many years, the copper in the mixture eventually becomes a pollutant .
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Fungicides can either be contact, translaminar or systemic. Contact fungicides are not taken up into the plant tissue and protect only the plant where the spray is deposited. Translaminar fungicides redistribute the fungicide from the upper, sprayed leaf surface to the lower, unsprayed surface.